CBD or cannabidiol is deprived of psychoactive properties, but it will help with various diseases
Recently, the topic of medical marijuana has been surfacing more and more regularly in foreign media, scientists are trying their utmost to obtain permissions and funding for research in this region, believing in its promise, and in several countries of the planet, decriminalization and legalization are underway.
Most hype now causes a substance such as for example CBD or cannabidiol contained in the hemp plant. Today it is found anywhere – from food to decorative cosmetics and quite legally purchased best cbd gummies uk in internet vendors in the shape of oil. And all because CBD does not need psychoactive properties, unlike tetrahydrocannabinol (THC), but it has healing properties.
Since CBD is an active element of marijuana itself, you may get make money from it by smoking a joint in the old fashioned way. The most important thing would be to ensure that a level with a predominance of this kind of substance, as opposed to THC, is clogged in your joint in the event that you only want to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to manage paranoia.
Let’s try to work out how this magical cannabidiol works, on the basis of the latest data from the planet of science and the experience of consumers using CBD as a medication, and not for fun.
The difference between the consequences of CBD and THC
Since cannabidiol is not a psychoactive substance, you can’t get high from it, but it’s easy to increase your productivity, relieve anxiety and relieve pain. When working with CBD, thoughts aren’t confused, memory does not deteriorate, and consequently of muscle relaxation, you may not turn into a vegetable, as is often the case with smoking cannabis varieties with a predominance of THC.
If the ratio of these substances is approximately the same, then you will see a slight euphoric and the above-mentioned beneficial effects at the same time. At once, such negative consequences as paranoia, dry mouth, blow drying and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are often due to THC, do not occur. Such varieties are frequently used as a painkiller.
Although CBD is effective alone, some experts still insist that in conjunction with other active the different parts of marijuana, it brings more benefits:
“To attain an improved therapeutic effect, you need a mix of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, first of all, by deficiencies in research data, because the field of studying the healing properties of hemp continues to be in its infancy. However the gradual legalization of medical marijuana suggests that scientists will quickly have more freedom for their experiments. So hold the fists, hope and believe.
What diseases cannabidiol helps to cope with
Some scientific papers claim that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope this substance can help pharmaceutical companies to produce effective drugs against many disorders and diseases combined with similar symptoms.
The list of such diseases includes, but isn’t restricted to such pathological conditions:
To date, you can find no full-fledged drugs predicated on CBD to combat these disorders, but many patients claim that the substance helps them to alleviate and even completely eliminate the symptoms.
Recently in the USA, where marijuana continues to be on the list of the very most dangerous psychoactive substances, there has been a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the very first marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of that your FDA has confirmed using its tests. Today, Epidiolex is employed to deal with severe forms of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there were other drugs on the basis of the the different parts of marijuana. For instance, the Belgian company Solvay Pharmaceuticals back 1985 created Marinol (dronabinol), a medication that’s simply an artificial THC, which is still used today to increase the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal parts of CBD and THC, to relieve muscle cramps and other outward indications of multiple sclerosis.
The mechanism of action of cannabidiol
Although there is still not really much data on how CBD includes a beneficial impact on the human body, scientists still involve some ideas with this subject. Surprisingly, cannabidiol does not bind to the active sites of the cannabinoid receptors CB1 and CB2, as does the same THC. Nonetheless it interacts with the GPR55 protein secreted in mental performance and peripheral organs. Researchers believe this determines its antispasmodic effect.
In mental performance, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted in one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more regularly than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, based on Ben Wally, head of research at GW Pharmaceuticals.
The partnership of this protein with CBD is confirmed by experiments with genetically modified rodents where epileptic seizures were caused. Those animals where GPR55 was present taken care of immediately cannabidiol treatment, and rats without protein continued to experience convulsions.
Wally also believes that CBD can contribute to the desensitization of the TRPV1 protein, which is mixed up in transport of ions and calcium in the body, which also helps relieve cramping. First, cannabidiol activates this protein, however quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not respond to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance produced by the body. Wally believes that cannabidiol suppresses seizures, mainly because impact on adenosine, but more experiments are needed to confirm this hypothesis.
This kind of wide range of areas where CBD is active allows scientists to suggest this substance may be useful in the treating motor disorders, such as for example Parkinson’s disease. And the interaction with serotonin receptors suggests that cannabidiol may be used to deal with depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for example Roger Pertwee, a professor at the University of Aberdeen and the pinnacle of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it cannot be confidently stated that the interaction of CBD with one of these receptors and proteins means so it causes a therapeutic effect of this substance.
High CBD Marijuana Varieties
Finally, we will provide you with a set of popular cannabidiol-dominated varieties so you know what to ask about next time in your telegram supermarket: